ABSTRACT
Background: In the last decade, there has been a revolution in chronic myeloid leukemia treatment with the introduction of tyrosine kinase inhibitors with imatinib mesylate becoming the frontline therapy. Objective: To evaluate the therapeutic efficacy of imatinib mesylate in treating chronic myeloid leukemia patients and to identify factors related to therapeutic efficacy. Methods: This retrospective study was based on information obtained from patients'records in the Hematology Service of Hospital Universitário Walter Cantídio of the Universidade Federal do Ceará (HUWC / UFC). All patients diagnosed with chronic myeloid leukemia that took imatinib mesylate for a minimum of 12 months in the period from January 2001 to January 2011 were included. From a population of 160 patients, 100 were eligible for analysis. Results: The study population consisted of 100 patients who were mostly male (51%) with ages rangingbetween 21 and 40 years (42%), from the countryside (59%), in the chronic phase (95%), with high-riskprognostic factors (40%); the prognosis of high risk was not associated with complete hematologic responseor complete cytogenetic response, but correlated to complete molecular response or major molecularresponse. Reticulin condensation was associated with complete hematologic response and completecytogenetic response. It was found that 53% of patients had greater than 90% adherence to treatment. Thehigh adherence was correlated to attaining complete cytogenetic response in less than 12 months. Moreover,20% of patients had good response. Conclusion: Significant changes are indispensable in the monitoring of patients with chronic myeloid leukemia. Thus, the multidisciplinary team is important as it provides access to the full treatment and not just to medications. .
Subject(s)
Young Adult , Middle Aged , Antineoplastic Protocols , Drug Therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy , Piperazines/therapeutic use , Protein-Tyrosine Kinases/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic useABSTRACT
O transplante de órgãos constitui uma última esperança de sucesso na recuperação de doenças em estágio terminal. A Enfermagem participa de forma atuante desde a captação do órgão até as consultas no ambulatório após o transplante, exigindo pessoal capacitado. Esse trabalho tem por objetivos identificar os principais diagnósticos de enfermagem em pacientes transplantados renais, em uma unidade de internação de um hospital de ensino no município de Fortaleza-Ce, e propor intervenções baseadas nas reais necessidades desses pacientes. Estudo descritivo-exploratório, de natureza qualitativa. A população foi constituída por pacientes transplantados em pós-operatório mediato e com complicações pós-transplante, sendo a amostra de doze pacientes. A coleta dos dados ocorreu através da aplicação de um histórico de enfermagem e para a análise foi abordada a seqüência das etapas do PE, utilizando-se a taxonomia II da NANDA. Foram identificados dezessete diagnósticos de enfermagem, o que permitiu a elaboração de intervenções baseadas nas reais necessidades desses pacientes. Acreditamos que, as intervenções sugeridas fundamentadas com referencial teórico, serão de suma importância para a prática dos enfermeiros que trabalham nessa área, e principalmente no hospital em questão.
The organs transplant is the last hope of success in the recovery of diseases in final stage. Nursing participates in an active way from getting the organs up till consultations after the transplant, requiring capable professionals. This paper?s goal is to identify the main nursing diagnosis in patients who underwent kidney transplant in an interned patients unit of a teaching hospital in the city of Fortaleza-CE, and propose interventions based on the real needs of these patients. Exploratory-descriptive study, with qualitative nature. The population was composed of patients in immediate post-operation and with complications, being the sample composed of twelve patients. The data collection was conducted through the application of a nursing recording and for analysis one approached the sequence of stages of NP, using the taxonomy II of NANDA. One identified seventeen nursing diagnoses, which allowed the elaboration of interventions based on the real needs of these patients. We believe that the interventions suggested based on theoretical reference, will be very important for the practice of nurses who work in this area, mainly in the hospital mentioned.
El transplante de órganos es la última esperanza de éxito en la recuperación de enfermedades terminales. La enfermería participa de manera actuante desde la captación del órgano hasta las consultas en el ambulatorio después del transplante, lo que exige personal capacitado. Este trabajo tiene por objetivo identificar los principales diagnósticos de enfermería en pacientes trasplantados renales en una unidad de internación de un hospital de enseñanza en el municipio de Fortaleza-CE y proponer intervenciones basadas en las reales necesidades de estos pacientes. Estudio descriptivo y exploratorio de naturaleza cualitativa. La población fue compuesta por pacientes transplantados en el postoperatorio inmediato y con complicaciones en el post transplante, la muestra fue de doce pacientes. La colecta de datos ocurrió a través de la aplicación de un histórico de enfermería y para el análisis fue abordada la secuencia de etapas del PE, utilizándose la taxonomia II de la NANDA. Fueron identificados diecisiete diagnósticos de enfermería, lo que permitió la elaboración de intervenciones basadas en las reales necesidades de eses pacientes. Así, creemos en la importancia para la práctica de los enfermeros que trabajan en ese área y principalmente en el hospital presentado.